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Assessment of Clinical Recovery of Equine Trypanosomosis using Antitrypanosomal Drugs and Antioxidant Supportive Therapy

R. K. Singh A. K. Tripathi A. Srivastava A. P. Singh
Vol 9(4), 94-102
DOI- http://dx.doi.org/10.5455/ijlr.20180927060618

The therapeutic efficacy of various antitrypanosomal drugs viz. diminazine aceturate, isometamedium chloride HCl and quinopyramine sulphate alone or in combination with vitamin E (antioxidant) were evaluated in naturally infected equines with T. evansi. Evaluation was done on the basis of alterations in the hemato-biochemical, oxidative stress parameters and percent recovery assessment on day 0 pretreatments, day 7th and day 14th post treatment. It can be infer from present study that all three drugs alone or along with vitamin E were effective against the trypanosomosis in equines but the extent of improvement in terms of hemato-biochemical values, oxidative stress parameters and percent recovery was observed maximum in the treatment with diminazine aceturate with vitamin E followed by isometamidium chloride hydrochloride with vitamin E and least with the quinapyramine sulphate. Therefore, the order of comparative therapeutic efficacy of anti-trypanosomal drugs in the present study has been found as diminazene aceturate with vitamin E, maximally effective followed by isometamidium chloride HCL with vitamin E and Quinapyramine sulphate was found to be least effective. Hence, diminazine aceturate along with vitamin E (antioxidant) could be successfully used in the treatment of equine trypanosomosis.

Keywords : Equine Hemato-Biochemical Oxidative Stress Percent Recovery Therapeutic Efficacy Trypanosomosis

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