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Effect of Amoxicillin on Haematobiochemical Parameters in Poultry

Madhuchhanda Khan Uttam Sarkar Tapan Kumar Mandal
Vol 8(4), 170-179
DOI- http://dx.doi.org/10.5455/ijlr.20170704045203

Amoxicillin, a broad-spectrum, β-lactam antibiotic is extensively used for empirical treatment of bacterial infections in poultry industry. Amoxicillin was administered orally to layer hen (Rhode Island Red) at therapeutic @20 mg kg -1 and at subtherapeutic (@10 mg kg -1 dose level for consecutive 14 days and the activities of some antioxidant enzymes and malondialdehyde (MDA) blood levels were studied. Amoxicillin produced a nonsignificant increase of haemoglobin , total leucocyte count and heterophil count in layer hens of different groups at different days compared to control group following daily oral administration for consecutive 14 days. On the other hand, Amoxicillin caused a nonsignificant decrease of lymphocyte and eosinophil count in layer hens of different groups at different days compared to control group. Values of blood glucose level and serum protein level of amoxicillin treated group of birds decreased nonsignificantly as compared to control birds. Plasma ALT, Plasma AST and serum lipid peroxidation activity in treated groups of layer poultry were increased significantly (P< 0.05) as compared to control birds. Erythrocyte catalase activity in treated groups of layer hens were decreased significantly (P< 0.05) on day 15 as compared to control birds. Erythrocyte superoxide dismutase activity in treated groups of layer hens were decreased significantly as compared to control birds (P<0.05) on day 15.

Keywords : Amoxicillin haematological parameter Antioxidant enzyme Malondialdehyde Reactive Oxygen Species

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