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Effect of Anesthetics Combination Ketamine and Xylazine on Mean Arterial Pressure of L-NAME Hypertensive Rats

Shahid Prawez Azad Ahmad Ahanger Thakur Uttam Singh Santosh Kumar Mishra Souvendra Nath Sarkar Shafiqur Rahman
Vol 8(4), 281-285
DOI- http://dx.doi.org/10.5455/ijlr.20170419030314

Hypertension is a known silent killer of both human and their close companion dogs, cats and horses. The disease becomes difficult to diagnose as anesthetics mask the actual reading of blood pressure of anaesthetized animal. The anesthetics Pentobarbital sodium, Ketamine and Xylazine alone and in combination are modifying the reading of mean arterial pressure (MAP). Hence, it becomes mandatory to know the effects of anesthetics on MAP. The rats were randomly divided into four groups viz. group-A (n=6), group-B (n=6), group-C (n=7) and group-D (n=5). The MAP of control rats of group A and B were measured under anesthetics Pentobarbital sodium and Ketamine and Xylazine in combination, respectively. However, the MAP of L-NAME-induced hypertensive rats of group-C and group-D were measured under anesthetics pentobarbital sodium and Ketamine and Xylazine in combination, respectively. The MAP of control rats of group-B significantly decreased under anesthetics Ketamine and Xylazine compared to rats of Pentobarbital group-A. Similarly, MAP of hypertensive rats of group-D significantly decreased under anesthetics Ketamine and Xylazine in combination to the level equivalence to MAP of group-A control rats indicting Ketamine and Xylazine combination significantly influencing the MAP of hypertensive rats. Hence, anesthetic combination of Ketamine and Xylazine should not be endorsed in animals since it masks the actual factual reading of MAP.

Keywords : Anesthetics Impede Ketamine Mean Arterial Pressure Wistar rats Xylazine

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