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Effect of Lead Intoxication on Antioxidant Defense in Erythrocytes of Broiler Chicken

Ritesh Jaiswal S.L. Ali S. Roy Sanjay Shakya Om Prakash Dinani Sudhir Kumar Jaiswal
Vol 7(7), 217-224

In the present study birds were divided into six groups viz. A, B, C, D, E and F. Group-A served as control (basal diet) where as all the other groups B,C,D,E and F were treated with lead acetate @ 200 mg/kg. In addition the groups C,D,E and F were also supplemented with Ascorbic acid @ 200 mg/kg, Vitamin-E @ 100/mg/kg and Se @ 0.1 mg/kg, DL-methionine @ 100 mg/ kg , methanolic extract of Cissus quadrangularis (CQE) @ 400 mg/kg respectively for 42 days. It was observed that lead administration enhanced the lipid peroxide (LPO) level in erythrocytes, result of simultaneous administration of lead with ascorbic acid, vitamin-E and Se, DL-methionine and CQE led to conclusion that vitamin-E and Se, DL-methionine and CQE were very effective in limiting the enhanced LPO level in erythrocyte. Maximum restoration in values of LPO level was observed in vitamin-E & Se treated group. Decreased erythrocytic glutathione (GSH) level in lead treated group was significantly (P<0.05) increased with the treatment of ascorbic acid. At the end of the study, there was significant (P<0.05) reduction in erythrocytic super oxide dismutase (SOD) and Catalase (CAT) activity in lead exposed birds. All the treatment given was found very efficacious as they enhanced SOD and CAT activities. However maximum restoration was recorded with the treatment of vitamin-E & Se.

Keywords : Lead Antioxidant Defense Erythrocytes Chicken

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