Health of an intact organism or its progeny depends on a proper-functioning of endocrine system to regulate the release of certain hormones that are essential for functions such as growth, metabolism, development, mood, sleep etc. Substances disrupting or interfering with normal hormonal balance and hence exerting adverse effects on health of an organism are known as Endocrine disrupting chemicals (EDCs). Principal toxic effects of EDCs were reported to be related to infertility, thyroid function disruption and teratogenicity, but other important toxic effects of EDCs such as carcinogenicity and mutagenicity have also been demonstrated. Large amounts of EDCs are found in aquatic environments from wastewater, industrial contamination and hospital runoffs. The exposure to EDCs to commercial and ecologically important marine and freshwater fish stocks has seriously affected their production. Current write up provides an assessment of recent investigations into endocrine disruption in fresh and aquatic life. We focused on natural or synthetic chemical compound in water that effect endocrine functioning in fishes.