Listeriosis in Animals and Humans
S. A. Bhat M. Shahnawaz S. N. Shah B. A. Ganayi C. P. S. Solanki
Vol 2(1), 68-77
Listeriosis is an emerging zoonotic infection of humans and ruminants worldwide caused by the bacterium Listeria monocytogenes. Listeriosis is one of the most important food-borne diseases of humans. The disease manifestations include septicaemia, meningitis and encephalitis, usually preceded by influenza-like symptoms including fever. In pregnant women, intrauterine or cervical infections may result in spontaneous abortion or stillbirths. Although the morbidity of listeriosis is relatively low, the mortality of the systemic/encephalitic disease can be very high, with values in the vicinity of 30%. In case of animals, clinical listeriosis is mainly a ruminant disease, with occasional sporadic cases in other species. The main clinical manifestations of animal listeriosis are encephalitis, septicaemia and abortion. This review discusses the current knowledge about listeric infection and involved host and bacterial factors. There is an urgent need to study the molecular mechanisms of pathogenesis, which are poorly understood. Such studies will provide a basis for the development of new therapeutic strategies that aim to prevent L. monocytogenes from invading the brain and spread within the CNS.
Keywords : Listeriosis Encephalitis zoonotic
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