Porcine circovirus- 2 (PCV2) is one such emerging viral pathogen of concern as it is involved in the Post-weaning Multisystemic Wasting syndrome (PMWS) resulting in losses to the farming community. The presence of PCV2 infection in Kerala was first reported in 2016 from Pookode in a research conducted on emerging viral diseases of swine. Thus the present research work was designed with the objectives of studying the gross and histopathological changes of PCV2 in piglets and confirmation of PCV2 antigen by immunohistochemistry (IHC). The gross examination of carcass revealed weak, poor body condition with visible bony prominence, systemic lymphadenopathy and non-collapsed lungs with varying degrees of congestion. Histological examination of the lymphoid and non-lymphoid tissues revealed lymphoid depletion and granulomatous inflammation respectively. This study confirms the presence of PCV2 infection among piglets in Thrissur districts of Kerala.