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Single Nucleotide Polymorphism Analysis in Exon 3 of Fshβ Gene in Holstein Friesian and Gir Crossbred Bull

Vijay K. Kadam Abhijit K. Barate Tejas C. Shende Hemant S. Birade
Vol 9(3), 313-319

Prediction of male fertility is of prime importance in production animals. Follicle-stimulating hormone (FSH) plays a pivotal role in the reproduction of mammals. Single nucleotide polymorphisms (SNPs) in FSHB gene have been reported to affect the semen quality and fertility in cattle. The present study aimed to characterize and analyze the presence of SNPs in the FSHB-3 of HFxG 5043 Indian crossbred bull. Analysis revealed that HFxG FSHB-3 has 99.2% homology at nucleotide level and 100% homology at amino acid level with cattle FSHB-3 sequences. Two SNPs were detected in the FSHB-3 sequence of HFxG (4314A>G and 4489A>C) compared to cattle M83753 sequence. Both SNPs detected in HFxG FSHB-3 sequence were synonymous i.e. they did not result in amino acid change in FSHB-3. Findings of this study may provide basis for future research on genetic mechanisms affecting the semen traits and marker assisted selection of such traits in Indian crossbred cattle.

Keywords : Crossbred Cattle FSHB SNP

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