A study was undertaken to evaluate the efficacy of endectocides, closantel and ivermectin in controlling the internal and external parasitic infestation in Osmanabad goats. One hundred and fifty Osmanabad goats reared under semi-intensive system were screened for endoparasites using faecal egg count method and those suffering were selected for the study. The study was carried out at Kalaburagi in Kalyana Karnataka and Osmanabad goats were randomly grouped into T1, T2 and T3 in equal numbers. The tick infestation was graded in the affected animals among different groups. Goats in T1 were not dosed with any of the drugs and were considered as Control. Goats in groups T2 and T3 were treated respectively with oral solutions of closantel (15%) and ivermectin (1%) at the rate of 1 ml and 0.40 ml per 20 kg body weight on day-1 and day -21.The animals were monitored for three months and parameters namely fecal egg count (FEC), texture of hair, number of ticks/sq inch, monthly body weight gain, haematology and economics were recorded. Reduction in FEC was significantly low in ivermectin group (T3) in comparison to T1 and T2. Coarse hairs in endectocide treated groups turned soft and lustrous by the end of third month and haemoglobin levels were significantly higher (p≤0.05) in both the treated groups. Numbers of ticks were reduced in both the groups and the reduction in number was noticed seven days after first treatment and was complete by first month. The body weight gain in treated groups was significantly higher (p≤0.05) compared to untreated control animals. Recovery and production performance was higher in T3 compared to T2. Ivermectin proved more effective over closantel in the control of ecto and endoparasites.