The present experiment was conducted on Magra lambs of 3-4 months of age at ARC-CSWRI for thirteen weeks to observe the effect of feeding dried distillers grains with solubles (DDGS) to magra lambs on sero-biochemical parameters. The lambs were used in a randomized block design and divided into four groups of 5 lambs in each group (T1-T4). Blood samples were collected at monthly interval by puncturing jugular vein following aseptic measures and serum was separated from each sample by standard procedure. No significant effect of incorporation of dried distillers grain with soluble i.e. DDGS was observed at each month of experimental period and also on overall mean values of serum glucose, serum creatinine, serum cholesterol and serum triglyceride. It was concluded that DDGS can be incorporated in lamb ration up to level of 15% without having any detrimental effect on health of lamb.