Research was carried out to know the individual and synergistic effect of cadmium chloride and chlorpyrifas on brain in wistar rats for a study period of 28 days in rats. Group 1: Control. Group 2: CdCl2 @ 22.5mg/ kg b.wt / oral. Group 3: CPF @ 25 mg/ kg b.wt /per oral. Group 4: CdCl2@22.5 mg + CPF @ 25 mg/ kg b.wt /per oral. Lower mean values of brain GSH & SOD were observed in G-4, 2 and 3 on 15th and 29th day when compared with G-1. Brain section of group 2 on 15th day revealed mild perivascular cuffing, on 29th day degeneration of Purkinje cells. Group 3 revealed gliosis on 15th day, on 29th day moderate perivascular cuffing and shrinkage of Purkinje cells. Brain sections of group 4 on 15th day revealed moderate multifocal perivascular cuffing and mild degeneration of Purkinje cells, on 29th day, the lesions were same but severe. The adverse neurotoxic effects in combined group were severe than individual groups due to synergistic action of the combined pollutants.