The present clinical study was conducted to study incidence, clinical symptoms and efficacy of different treatment modalities on bovine papillomatosis. Among total of 3812 cattle presented to the clinic, 52 cattle were having papillomas. No incidence of papillomas was recorded in buffaloes. Thirty cattle with bovine papillomatosis were divided into 5 groups of 6 animals each and were treated with subcutaneous administration of ivermectin, autohaemotherapy, autogenous vaccine, surgical excision and tarantula cubensis extract administration respectively. Highest incidence of bovine papillomas was observed in cattle of 3 years age. Jersey crossbred cows were the most commonly affected breed followed by HF cross breed and non – descript cows. Most of the papillomas were located on teats only (40.38%) followed by teats and udder (21.15%). Histopathologically, fibropapilloma (60%) was found to be most common papilloma followed by angiokeratotic acanthomatous papilloma (40%). Immunohistochemical studies were conducted to know the rate of proliferation of bovine papillomas. Immunopositive reaction was observed against VEGF in angiokeratotic acanthomatous papilloma. EGFR and Ki67 immunopositivity was observed in fibropapillomas. Tarantula cubensis extract was found to be efficacious in the treatment of bovine papillomatosis with no occurrence for a period of 6 months.