In present investigation 197 calves having dermatological problem were examined. Out of them, 20 calves were found positive for Sarcoptic scabei var. bovis were screened and randomly divided in two treatment groups, A and B. Calves of Group-A treated with Ivermectin and Amitraz combination while Group- B treated with herbal combination and Group-C, kept as healthy control. Pre-treatment (0 day) evaluation of haemato biochemical parameters of both groups revealed significant (P<0.05) decrease in Hb, PCV and TEC, neutrophils, serum glucose, total protein, albumin, globulin, A:G ratio, Cu and Zn level and significant (P<0.05) increase in ESR, TLC, eosinophils, lymphocytes, ALT and AST value as compared to healthy control group. On 35th day of post treatment, skin scrapings were found negative, disappearance of clinical manifestations and restoration haemato-biochemical parameters towards normalcy in both treatment groups. Calves treated with Ivermectin and Amitraz combination showed faster recovery as compared to herbal combination.