The present study was undertaken to evaluate the therapeutic efficacy of imidocarb dipropionate and oxytetracycline-doxycycline combination therapy on the basis of improvement in clinical, haemato-biochemical parameters in ehrlichiosis in dogs. Total 12 dogs positive for ehrlichia were selected for the study and randomly divided into 2 groups. First group of ehrlichia positive dogs was treated with oxytetracycline @ 22 mg/kg body weight intravenously for 3 days followed by doxycycline @ 10 mg/kg body weight orally for 21 days along with supportive therapy. Second group of 6 ehrlichia positive dogs was treated with two doses of Imidocarb dipropionate @ 6 mg/kg body weight intramuscularly at 14 days intervals along with supportive treatment. The study concluded that both the drugs found effective against ehrlichiosis in dogs along with improvement in clinical and haemato-biochemical parameters. However, imidocarb dipropionate demonstrated faster recovery on the basis of improvement in clinical and haemato-biochemical parameters than the long-term treatment with oxytetracycline – doxycycline combination therapy in ehrlichia infected dogs.