The present study was carried out on twenty-four lactating Murrah buffaloes during summer months in 2016 in experimental sheds with or without microclimate alteration devices as four treatment groups (six buffaloes in each group) viz. foggers (T1), fans (T2), fans and feed additive (T3) and control group (C). Mean haemoglobin (Hb) levels were significantly (P<0.01) different and higher in C group of buffaloes followed by T3, T2 and T1 groups. Packed cell volume (PCV) and total erythrocyte count (TEC) were higher in C group followed by T2, T3 and T1 group animals. Mean total leukocyte count and erythrocyte indices including mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) did not differ significantly among the groups. Neutrophils (%) were higher in T3 group followed by T1, T2 and C group animals, whereas lymphocytes (%) were higher in C group followed by T2, T1 and T3 group animals. Monocytes and Eosinophils did not differ significantly.