This experiment was conducted to evaluate the effects of dietary inclusion of rice distillers dried grains with solubles (RDDGS) with and without enzyme on growth performance and nutrient digestibility of broilers. The 240-day-old broiler chicks were randomly allocated to six groups with four replicates. During this experiment starter, grower and finisher period, experimental diets were fed to birds which were isonitrogenous and isocaloric formulated with different levels of RDDGS. They were T1 (control, without RDDGS and enzyme), T2 (control, without RDDGS and with cocktail of enzyme @100g/q feed), T3 (10% RDDGS), T4 (10% RDDGS with cocktail of enzyme @100g/q feed), T5 (15% RDDGS), T6 (15% RDDGS with cocktail of enzyme @100g/q feed). Growth performance parameters like body weight gain, feed intake, FCR, PER and CER were monitored weekly. The results showed that in growth performance parameters, RDDGS inclusion at 10% with and without enzyme had higher body weight gain but feed intake, FCR, PER and CER did not show any significant difference at different inclusion levels as compared to control groups. Nutrient utilization (dry matter, crude protein digestibility and calcium retention) were significantly higher in 10% RDDGS with and without enzyme treatments. Thus, it was concluded that RDDGS can be safely incorporated in broiler chickens diets up to the inclusion level of 15% but best results were seen at 10% inclusion as alternate protein meal for economic broiler production.