This report describes the pathology of avian cholera in an adult female fish eagle (Haliaeetus vocifer) from a group of raptors captured from the wetlands of Brass about 100km radius on the Atlantic flyway in Bayelsa State, Nigeria. The diagnosis of avian cholera considered the clinical history, gross and microscopic lesions, cultural isolation and characterisation of Pasteurella multocida. The impact of avian cholera and other infectious diseases on raptor and migratory birds populations needs to be well monitored primarily for conservation purposes, disease transmission pattern and for control measures to be properly implemented in the capital entrusted poultry industry.