Patho-morphological and immunohistochemical investigation of a natural outbreak of PPR was carried out in Osmanabadi goat in Nagpur (Central India). The flock morbidity and mortality were 100% and 60% respectively. Gross examination revealed erosive stomatitis, cranioventral consolidation of an apical lobe of lungs and hemorrhagic enteritis with characteristic streaks of hemorrhages in the terminal ileum. Microscopically, lungs revealed diffuse infiltration of mononuclear cells, multinucleated syncytia formation and characteristic intracytoplasmic and intranuclear eosinophilic inclusions in the bronchiolar epithelium and alveolar macrophages. Lymphoid organs revealed marked depletion of lymphocytes. PPR viral antigen was detected in the cytoplasm of the bronchiolar epithelium, alveolar macrophages and, epithelial cells of the intestine with immunohistochemistry. Phylogenetic analysis confirmed the involvement of the lineage IV of PPRV.