Assessment of Clinical Recovery of Equine Trypanosomosis using Antitrypanosomal Drugs and Antioxidant Supportive Therapy

Abstract

The therapeutic efficacy of various antitrypanosomal drugs viz. diminazine aceturate, isometamedium chloride HCl and quinopyramine sulphate alone or in combination with vitamin E (antioxidant) were evaluated in naturally infected equines with T. evansi. Evaluation was done on the basis of alterations in the hemato-biochemical, oxidative stress parameters and percent recovery assessment on day 0 pretreatments, day 7^th and day 14^th post treatment. It can be infer from present study that all three drugs alone or along with vitamin E were effective against the trypanosomosis in equines but the extent of improvement in terms of hemato-biochemical values, oxidative stress parameters and percent recovery was observed maximum in the treatment with diminazine aceturate with vitamin E followed by isometamidium chloride hydrochloride with vitamin E and least with the quinapyramine sulphate. Therefore, the order of comparative therapeutic efficacy of anti-trypanosomal drugs in the present study has been found as diminazene aceturate with vitamin E, maximally effective followed by isometamidium chloride HCL with vitamin E and Quinapyramine sulphate was found to be least effective. Hence, diminazine aceturate along with vitamin E (antioxidant) could be successfully used in the treatment of equine trypanosomosis.