Transboundary Spread of Lumpy Skin Disease with Emphasis on Diagnosis and Control


  • Rita Grace Sacharia MVSC Scholar, Department of Veterinary Epidemiology and Preventive Medicine College of Veterinary & Animal Sciences, Pookode, Wayanad, Kerala, INDIA
  • P. M. Deepa Assistant Professor & Head, Department of Veterinary Epidemiology and Preventive Medicine College of Veterinary & Animal Sciences, Pookode, Wayanad, Kerala, INDIA



Cattle, Control, Diagnosis, Lumpy Skin Disease, Virus


Lumpy skin disease is a disease which had its origin from Africa and spread almost to three by fourth of the globe. Though it may not be zoonotic and do not cause high mortality rate in animals, it is a disease of great importance as it cause high economic loss. The disease is caused by a strain of pox virus and cannot be effectively controlled by quarantine or other safety measures alone as the spread of the disease depends on the population of blood sucking parasites. The population of blood sucking parasites depends on the temperature and humidity and studies have shown that rising global warming and rise of temperature has increased the rate of progression of the disease. Vaccination alone as a control method lack efficiency hence other measures like vector control, isolation of affected animals, quarantine of newly purchased animals and restriction of movement of animals are implemented simultaneously along with vaccination strategies.


Alexander, S., Olga, B., Svetlana, K., Valeriy, Z., Yana, P., Pavel, P., & Aleksandr, K. (2019). A real-time PCR screening assay for the universal detection of lumpy skin disease virus DNA. BMC research notes, 12(1), 371. DOI:10.1186/s13104-019-4412-z

Al-Salihi, K. (2014). Lumpy skin disease: Review of literature. Mirror of Research in Veterinary Sciences and Animals, 3(3), 6-23.

Awad, W. S., Ibrahim, A. K., Mahran, K., Fararh, K. M., & Moniem, M. I. A. (2010). Evaluation of different diagnostic methods for diagnosis of lumpy skin disease in cows. Tropical Animal Health and Production, 42(4), 777-783. DOI: 10.1007/s11250-009-9486-5

Ayelet, G., Abate, Y., Sisay, T., Nigussie, H., Gelaye, E., Jemberie, S., & Asmare, K. (2013). Lumpy skin disease: preliminary vaccine efficacy assessment and overview on outbreak impact in dairy cattle at Debre Zeit, central Ethiopia. Antiviral research, 98(2), 261-265. DOI:10.1016/j.antiviral.2013.02.008

Babiuk, S. (2018). Vaccines against LSD and vaccination Strategies. In Lumpy Skin Disease (pp. 85-93). Springer, Cham. DOI: 10.1007/978-3-319-92411-3_18

Babiuk, S., Bowden, T. R., Boyle, D. B., Wallace, D. B., & Kitching, R. P. (2008). Capripoxviruses: an emerging worldwide threat to sheep, goats and cattle. Transboundary and emerging Diseases, 55(7), 263-272. DOI: 10.1111/j.1865-1682.2008.01043.x

Ben-Gera, J., Klement, E., Khinich, E., Stram, Y., & Shpigel, N. Y. (2015). Comparison of the efficacy of Neethling lumpy skin disease virus and x10RM65 sheep-pox live attenuated vaccines for the prevention of lumpy skin disease–The results of a randomized controlled field study. Vaccine, 33(38), 4837-4842. DOI: 10.1016/j.vaccine.2015.07.071

Body, M., Singh, K. P., Hussain, M. H., Al-Rawahi, A., Al-Maawali, M., Al-Lamki, K., & Al-Habsy, S. (2012). Clinico-histopathological findings and PCR based diagnosis of lumpy skin disease in the Sultanate of Oman. Pakistan Veterinary Journal, 32(2), 206-210.

Bowden, T. R., Coupar, B. E., Babiuk, S. L., White, J. R., Boyd, V., Duch, C. J., ... & Boyle, D. B. (2009). Detection of antibodies specific for sheeppox and goatpox viruses using recombinant capripoxvirus antigens in an indirect enzyme-linked immunosorbent assay. Journal of Virological Methods, 161(1), 19-29. DOI: 10.1016/j.jviromet.2009.04.031

Brenner, J., Bellaiche, M., Gross, E., Elad, D., Oved, Z., Haimovitz, M. & Yadin, H. (2009). Appearance of skin lesions in cattle populations vaccinated against lumpy skin disease: statutory challenge. Vaccine, 27(10), 1500-1503. DOI: https:10.1016/j.vaccine.2009.01.020

Buller, R. M., Arif, B. M., Black, D. N., Dumbell, K. R., Esposito, J. J., Lefkowitz, E. J& Skinner, M. A. (2005). Poxviridae. Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA. eds. Virus Taxonomy: Eight Report of the International Committee on the Taxonomy of Viruses. Elsevier/Academic Press, Oxford, 117-33.

Capstick, P. B., Prydie, J., Coackley, W., & Burdin, M. L. (1959). Protection Of cattle against 'Neethling' type virus of lumpy skin disease. Veterinary Record, 71, 422.

Carn, V. M., Kitching, R. P., Hammond, J. M., & Chand, P. (1994). Use of a recombinant antigen in an indirect ELISA for detecting bovine antibody to capripoxvirus. Journal of virological methods, 49(3), 285-294. DOI:10.1016/0166-0934(94)90143-0

Carn, V. M., & Kitching, R. P. (1995). An investigation of possible routes of transmission of lumpy skin disease virus (Neethling). Epidemiology & Infection, 114(1), 219-226. DOI:10.1017%2Fs0950268800052067

Casal, J., Allepuz, A., Miteva, A., Pite, L., Tabakovsky, B., Terzievski, D. & Beltrán‐Alcrudo, D. (2018). Economic cost of lumpy skin disease outbreaks in three Balkan countries: Albania, Bulgaria and the Former Yugoslav Republic of Macedonia (2016‐2017). Transboundary and Emerging Diseases, 65(6), 1680-1688. DOI: 10.1111/tbed.12926

Chihota, C. M., Rennie, L. F., Kitching, R. P., & Mellor, P. S. (2001). Mechanical transmission of lumpy skin disease virus by Aedes aegypti (Diptera: Culicidae). Epidemiology & Infection, 126(2), 317-321. DOI: 10.1017/S0950268801005179

Davies, F. G., Krauss, H., Lund, J., & Taylor, M. (1971). The laboratory diagnosis of lumpy skin disease. Research in Veterinary Science, 12(2), 123-128. DOI: 10.1016/S0034-5288(18)34204-8

European Food Safety Authority (EFSA), Calistri, P., DeClercq, K., Gubbins, S., Klement, E., Stegeman, A & Gogin, A. (2019). Lumpy skin disease: III. Data collection and analysis. EFSA Journal, 17(3), e05638. DOI: 10.2903/j.efsa.2019.5638

El-Kholy, A. A., Soliman, H. M., & Abdelrahman, K. A. (2008). Polymerase chain reaction for rapid diagnosis of a recent lumpy skin disease virus incursion to Egypt. Arab Journal of Biotechnology, 11, 293-302.

Gari, G., Biteau-Coroller, F., LeGoff, C., Caufour, P., & Roger, F. (2008). Evaluation of indirect fluorescent antibody test (IFAT) for the diagnosis and screening of lumpy skin disease using Bayesian method. Veterinary microbiology, 129(3-4), 269-280 DOI: 10.1016/j.vetmic.2007.12.005

Gari, G., Waret-Szkuta, A., Grosbois, V., Jacquiet, P., & Roger, F. (2010). Risk factors associated with observed clinical lumpy skin disease in Ethiopia. Epidemiology & Infection, 138(11), 1657-1666. DOI: 10.1017/S0950268810000506

Gari, G., Grosbois, V., Waret-Szkuta, A., Babiuk, S., Jacquiet, P., & Roger, F. (2012). Lumpy skin disease in Ethiopia: Seroprevalence study across different agro-climate zones. Acta tropica, 123(2), 101-106. DOI:10.1016/j.actatropica.2012.04.009

Green, H. F. (1959). Lumpy skin disease: its effect on hides and leather and a comparison on this respect with some other skin diseases. Bulletin of Epizootic Diseases of Africa, 7, 63-79.

Gupta, T., Patial, V., Bali, D., Angaria, S., Sharma, M., & Chahota, R. (2020). A review: Lumpy skin disease and its emergence in India. Veterinary Research Communications, 1-8. DOI:10.1007/s11259-020-09780-1

House, J. A., Wilson, T. M., Nakashly, S. E., Karim, I. A., Ismail, I., Danaf, N. E. & Ayoub, N. N. (1990). The isolation of lumpy skin disease virus and bovine herpesvirus-from cattle in Egypt. Journal of Veterinary Diagnostic Investigation, 2(2), 111-115. DOI:10.1177%2F104063879000200205

Irons, P. C., Tuppurainen, E. S. M., & Venter, E. H. (2005). Excretion of lumpy skin disease virus in bull semen. Theriogenology, 63(5), 1290-1297. DOI:10.1016/j.theriogenology.2004.06.013

Kitching, P. (1983). Progress towards sheep and goat pox vaccines. Vaccine, 1(1), 4-9. DOI:10.1016/0264-410X(83)90004-X

Kitching, R. P., Hammond, J. M., & Taylor, W. P. (1987). A single vaccine for the control of capripox infection in sheep and goats. Research in Veterinary Science, 42(1), 53-60. DOI:10.1016/s0034-5288(18)30655-6

Lamien, C. E., Lelenta, M., Goger, W., Silber, R., Tuppurainen, E., Matijevic, M. & Diallo, A. (2011). Real time PCR method for simultaneous detection, quantitation and differentiation of Capri poxviruses. Journal of Virological Methods, 171(1), 134-140. DOI: 10.1016/j.jviromet.2010.10.014

Lefevre, P. C., Blancou, J., & Chermette, R. (2010). Infectious and parasitic diseases of livestock. Lavoisier.

Lu, G., Xie, J., Luo, J., Shao, R., Jia,K &Li.S.(2020). Lumpy skin disease outbreaks in China since 3 August 2019. Transboundary and Emerging Diseases, Oct 29.

MacDonald, R. A. S. (1931). Pseudo-urticaria of cattle. Government of Northern Rhodesia: Department of Animal Health, 20-1.

MacOwan, K. D. S. (1959). Observations on the epizootiology of lumpy skin disease during the first year of its occurrence in Kenya. Bulletin of Epizootic Diseases of Africa, 7, 7-20.

Milovanović, M., Dietze, K., Milićević, V., Radojičić, S., Valčić, M., Moritz, T., & Hoffmann, B. (2019). Humoral immune response to repeated lumpy skin disease virus vaccination and performance of serological tests. BMC veterinary research, 15(1), 80. DOI:10.1186/s12917-019-1831-y

Rahman, Md. Sahidur, (2020). Outbreaks of Lumpy Skin Disease of Cattle in Bangladesh: What to Know and What to Do. Available at

Rossiter, P. B., & Al Hammadi, N. (2009). Living with transboundary animal diseases (TADs). Tropical Animal Health and Production, 41(7), 999. DOI: 10.1007/s11250-008-9266-7

Rouby, S., & Aboulsoud, E. (2016). Evidence of intrauterine transmission of lumpy skin disease virus. The Veterinary Journal, 209, 193-195. DOI: 10.1016/j.tvjl.2015.11.010

Şevik, M., & Doğan, M. (2017). Epidemiological and molecular studies on lumpy skin disease outbreaks in Turkey during 2014–2015. Transboundary and Emerging Diseases, 64(4), 1268-1279. DOI:10.1111/tbed.12501

Shimshony, A., & Economides, P. (2006). Disease prevention and preparedness for animal health emergencies in the Middle East. Revue scientifique et technique-Office international des épizooties, 25(1), 253.

Sprygin, A., Pestova, Y., Wallace, D. B., Tuppurainen, E., & Kononov, A. V. (2019). Transmission of lumpy skin disease virus: a short review. Virus research, 269, 197637. DOI:10.1016/j.virusres.2019.05.015

Stram, Y., Kuznetzova, L., Friedgut, O., Gelman, B., Yadin, H., & Rubinstein-Guini, M. (2008). The use of lumpy skin disease virus genome termini for detection and phylogenetic analysis. Journal of virological methods, 151(2), 225-229. DOI: 10.1016/j.jviromet.2008.05.003

Sudhakar, B.S., Mishra, N., Kalaiyarasu, S., Jhade, S. K., Hemadri, D., Sood, R., Bal, G.C., Nayak, M.K., Pradhan, S.K & Singh, V.P.(2020). Lumpy skin outbreaks in cattle in Odisha state, India in August 2019: Epidemiological features and molecular studies. Transboundary and Emerging diseases, 1-15. DOI: 10.1111/tbed.13579

Thomas, A. D & Mare, C.V.E (1945). Knopvelsiekte. Journal of the South African Veterinary Association, 16(1), 36-43.

Tuppurainen, E. S. M, Stoltsz, W. H., Troskie, M., Wallace, D. B., Oura, C. A. L., Mellor, P. S. & Venter, E. H. (2011). A potential role for ixodid (hard) tick vectors in the transmission of lumpy skin disease virus in cattle. Transboundary and emerging diseases, 58(2), 93-104. DOI: 10.1111/j.1865-1682.2010.01184

Tuppurainen, E. S. M., & Oura, C. A. L. (2012). Lumpy skin disease: an emerging threat to Europe, the Middle East and Asia. Transboundary and emerging diseases, 59(1), 40-48. DOI:10.1111/j.1865-1682.2011.01242

Vohra, N. & Wattamwar, S. (2020). Lumpy Skin Disease (LSD): An Economic Crisis among Farmers. Vigyan Varta 1 (2), 66-68.

Von Backstrom, U. (1945). Ngamiland cattle disease: preliminary report on a new disease, the etiological agent being probably of an infectious nature. Journal of the South African Veterinary Association, 16(1), 29-35.

Weiss, K. E. (1968). Lumpy skin disease virus. In Cytomegaloviruses. Rinderpest Virus. Lumpy Skin Disease Virus (pp. 111-131). Springer, Berlin, Heidelberg. DOI: 10.1007/978-3-662-39771-8_3

Yeruham, I., Perl, S., Nyska, A., Abraham, A., Davidson, M., Maymovitch, M., & Grinstein, H. (1994). Adverse reactions in cattle to a capripox vaccine. Veterinary Record, 135(14), 330-332.

Zeynalova, S., Asadov, K., Guliyev, F., Vatani, M., & Aliyev, V. (2016). Epizootology and molecular diagnosis of lumpy skin disease among livestock in Azerbaijan. Frontiers in Microbiology, 7, 1022. DOI:10.3389/fmicb.2016.01022

Zeedan, G. S. G., Mahmoud, A. H., Abdalhamed, A. M., & Abd El, K. A. E. H. (2019). Detection of lumpy skin disease virus in cattle using real-time polymerase chain reaction and serological diagnostic assays in different governorates in Egypt in 2017. Veterinary World, 12(7), 1093. DOI: 10.14202/vetworld.2019.1093-1100




How to Cite

Sacharia, R. G., & Deepa, P. M. (2021). Transboundary Spread of Lumpy Skin Disease with Emphasis on Diagnosis and Control. International Journal of Livestock Research, 11(1), 22–29.

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