Haemodynamic Study Following Epidural Administration of Tramadol and Butorphanol in Combination of Lignocaine Hydrochloride in Goats

Arvind Kumar Sharma; Dayanand Turi; Reetu Tirkey; Bidyabhushan Kumar; Vinod Kumar; Anand Kumar

doi:10.5455/ijlr.20201229065628

Authors

Arvind Kumar Sharma Asst. Professor (SS) and Head, Dept. of Vet. Surgery and Radiology, Ranchi Veterinary College, B.A.U., Kanke, Ranchi, Jharkhand, India
Dayanand Turi Touring Veterinary officer, Animal Husbandry Department, Jharkhand, India
Reetu Tirkey Asst. Professor, Dept. of Vet. Surgery and Radiology, Ranchi Veterinary College, B.A.U., Kanke, Ranchi, Jharkhand, India
Bidyabhushan Kumar Teaching Associate, Dept. of Vet. Clinical Complex, Ranchi Veterinary College, B.A.U., Kanke, Ranchi, Jharkhand, India
Vinod Kumar Teaching Associate, Dept. of Vet. Surgery and Radiology, Ranchi Veterinary College, B.A.U., Kanke, Ranchi, Jharkhand, India
Anand Kumar Assistant Professor, Dept. of Vet. Gynaecology and Obstetrics, Ranchi Veterinary College, B.A.U., Kanke, Ranchi, Jharkhand, India

DOI:

https://doi.org/10.5455/ijlr.20201229065628%20%20%20%20%20%20%20

Keywords:

Butorphanol, Goats, Haemodynamic Changes, Lignocaine, Tramadol

Abstract

The objective of the study was to compare the haemodynamic changes in goats after epidural administration of lignocaine alone and in combination with butorphanol and tramadol. A total of 18 clinically healthy goats of 1-2 years of age and weighing between 12-15 kg were randomly divided in three groups containing six goats in each. Group I was treated with inj. lignocaine hydrochloride @ 4 mg/kg bwt. Epidurally in the lumbosacral space, whereas goats of group II and III received inj. lignocaine Hcl in the same dose rate in combination with inj. butorphanol tartrate @0.04 mg/kgbwt and inj. tramadol hydrochloride@ 1 mg/kgbwt, respectively. A significant decrease in the value of SAP was found at 15 min in group II and at 30 min in group III. Diastolic and mean arterial pressure did not show significant variation within and among the groups. The animals of group II showed a significant bradycardia (P<0.05) as depicted by increase in R-R and Q-T intervals. It is concluded that the epidural administration of lignocaine in combination of butorphanol and tramadol produces transient alteration in haemodynamic alterations thus these agents are considered as safer agents for achieving analgesia.

References

Ahmad, J. A. and Sanyal, S. (2008). Electrocardiographic studies in Garol sheep and Black Bengal goats. Research Journal of Cardiology, 1,1-8.

Altunkaya, H., Ozer, Y., Kargi, E. and Babuccu, O. (2003). Comparison of local anaesthetic effects of tramadol with prilocaine for minor surgical procedures. British Journal of Anaesthesia, 90, 320-22.

DeRossi, R., Junqueira, A. L. and Lopes, R. A. (2005). Use of ketamine or lidocaine or in combination for subarachnoid analgesia in goats. Small Ruminant Research, 59,95-101.

Dias, R.S.G., Soares, J. H. N., Castro, D.d.S.E., Gress, M.A.K.D.A., Machado, M.L., Otero, P.E. and Ascoli, F.O. (2018). Cardiovascular and respiratory effects of lumbosacral epidural bupivacaine in isoflurane anaesthetized dogs: the effects of two volumes of 0.25% solution. PLOS one, 13(4): e0195867

Geddes, LA., Combs, W. and Denton, W. (1980). Indirect mean arterial pressure in the anaesthetized dog. American Journal of Physiology, 238, 664-666.

Kinjavdekar, P., Aithal, H. P., Amarpal, Pawde, A.M., Pratap,K. and Singh, G.R. (2006). Potential effect of romifidine with lidocaine administration in goats. Small Ruminant Research, 64 (3), 293-304.

Mohan, N.H., Niyogi, D. and Singh, N.H. (2005). Analysis of normal electrocardiograms of Jamunapari goats. Journal of Veterinary Science, 6, 295-298.

Naeine, A.T., Rezakhani, A. and Fazlinia, J. (2004). Clinical evaluation of epidural administration of morphine, fentanyl, methadone, lidocaine and lidocaine with epinephrine in cattle. Pakistan Veterinary Journal, 24(1),31-32.

Natalini, C.C. and Robinson, E.P. (2000). Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol, and U50488H in horses. American Journal of Veterinary Research, 61, 1579-1586.

Pepe, S., van den Brink, O.W.V., Lakatta, E.G. and Xiao, R. P. (2004). Cross – talk of opioid peptide receptor and h- adrenergic receptor signalling in the heart. Cardiovascular Research, 63, 414 – 422.

Popio, K.A., Jackson, D.H., Ross, A.M., Schreiner, B.F. and Yu, P.N. (1978). Hemodynamic and respiratory effects of morphine and butorphanol. Clinical Pharmacology and. Therapeutics, 23,281-287.

Raina, R., Verma, P.K., Pankaj, N.K., Prawez, S. and Srivastava, A.K. (2008). Effect of tramadol on electrocardiogram, mean electrical axis and Respiration in Kagani Goats (Capra hircus). Iranian Journal of Pharmacology and Therapeutics, 7(2),157-160.

Santos, P.S.P., Nunes, N., vicenti, F.A.M., Martins, S.E.C. and Rezend, M.C. (2004). Electrocardiography of dogs undergoing different desflurane concentration. Ciencia-Rural (online), 34(4), 1105-1111.

Snedecor, G.W. and Cochran, W.G. (2004). Statical methods 8th Edn. lowa State University press, Ames, lowa.

Staffieri, F., Driessen, B., Lacitignola, L. and Crovace, A. (2009). A comparison of subarachnoid buprenorphine or xylazine as an adjunct to lidocaine for analgesia in goats. Veterinary Anesthesia and analgesia, 36(5): 502-511.

Thurston, C.L., Stames, A. and Randich, A. (1993). Changes in nociception, arterial blood pressure and heart rate produced by intravenous morphine in the conscious rat. Brain Research, 612,70–77.

Vnuk, D., Nesek- Adam, V., Pecin, M., Musulin, A., Lemo, A., Brajenovic, N., Brcic Karacorij, I., Radisic, B., Smolec, O. and Lipar, M. (2011). Haemodynamic effects of epidural lidocaine vs lidocaine adrenaline. Veterinarski arhiv,81(5): 585-595.