Oxyclozanide Poisoning in Deoni Bulls and its Therapeutic Management

Ravindra K. Jadhav; Sambhaji G. Chavhan

Authors

Ravindra K. Jadhav Assistant Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Udgir. Maharashtra Animal and Fishery Sciences University, Nagpur.
Sambhaji G. Chavhan Assistant Professor, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Udgir. Maharashtra Animal and Fishery Sciences University, Nagpur. https://orcid.org/0000-0001-9100-5699

Keywords:

Cattle, Clinical Signs, Hemato-biochemical changes, Oxyclozanide Toxicity, Treatment

Abstract

Three Deoni bulls were admitted to clinics with a history of anorexia, abdominal pain, and diarrhea with straining due to accidental overdosing of a combination comprising Oxyclozanide and Fenbendazole. Clinical examination revealed tachycardia, normal body temperature, and respiration rate along with slight salivation, loose foul-smelling feces, suspended rumination, absence of ruminal motility and signs of abdominal colic. Hematological analysis before treatment showed all parameters within normal reference intervals except a mild increase in monocyte count. Serum biochemical analysis revealed elevated levels of hepatic enzymes, blood urea nitrogen, and creatinine. As no specific antidote is available, the cases were treated symptomatically using fluid therapy, antihistaminics, vitamin B complex, and prebiotics- probiotics for 3 days. All three bulls recovered successfully after 3 days of treatment with restoration of food and water intake and rumination. In conclusion, oxyclozanide + fenbendazole poisoning may be observed in cattle due to accidental overdosing characterized by anorexia, salivation, abdominal pain and diarrhea with straining along with elevated levels of hepatic and renal biochemical markers. The extent of overdose and severity of clinical signs may decide the outcome of treatment as there is no specific antidote for oxyclozanide + fenbendazole toxicity in cattle.

Author Biographies

Ravindra K. Jadhav, Assistant Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Udgir. Maharashtra Animal and Fishery Sciences University, Nagpur.

Assistant Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Udgir. Maharashtra Animal and Fishery Sciences University, Nagpur.

Sambhaji G. Chavhan, Assistant Professor, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Udgir. Maharashtra Animal and Fishery Sciences University, Nagpur.

Assistant Professor, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Udgir. Maharashtra Animal and Fishery Sciences University, Nagpur.

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