Immunogenicity and Safety of a Classical Swine Fever Vaccine in Pigs

Authors

  • S. P. Veera Senior Manager, Veterinary Services Department, Indian Immunologicals Ltd., Hyderabad, Telangana, INDIA
  • D. Rathanamma Professor and Head, Department of Veterinary Microbiology, KVAFSU, Bangalore, Karnataka, INDIA
  • Buddhe Ekambaram Professor, Department of LFC, PVNR Telangana Veterinary University, Hyderabad, Telangana, INDIA
  • S. B. Prasanna Associate Professor, Department of LFC, KVAFSU, Bangalore, Karnataka, INDIA
  • Y. Kankarne Executive, Veterinary Services Department, Indian Immunologicals Ltd., Hyderabad, Telangana, INDIA
  • K. Srinivas Deputy General Manager, Quality Control Department, Indian Immunologicals Ltd., Hyderabad, Telangana, INDIA
  • Suprita Sinha Deputy Manager, Veterinary Services Department, Indian Immunologicals Ltd., Hyderabad, Telangana, INDIA

DOI:

https://doi.org/10.5455/ijlr.20200316015559%20%20%20%20

Keywords:

Classical Swine Fever, Field Trial, Immunogenicity, Safety, Vaccine

Abstract

Field trial of Classical Swine Fever vaccine, manufactured by Indian Immunologicals Limited, was undertaken at Bangalore and Hyderabad Veterinary Colleges. The study was designed to assess the immunogenicity and safety in pigs. A total of 80 healthy pigs which were seronegative for Classical Swine Fever virus antibodies were used for the trial. Pigs were enrolled on the basis of eligibility criteria. Animals were randomly divided into two groups in the ratio of 3:1. Group-I, treatment group, received the vaccine and Group-II, control group, received normal saline. Immunogenicity was compared by estimating seroconversion at 30 days post- vaccination between both the groups. Safety of vaccine was assessed during vaccination and in the follow-up period after vaccination. Hundred percent (100%) seroconversion was observed in the treatment group at 30th day. The investigational vaccine was found to be safe as it showed no serious or adverse events following vaccination.

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Published

30-06-2020

How to Cite

Veera, S. P., Rathanamma, D., Ekambaram, B., Prasanna, S. B., Kankarne, Y., Srinivas, K., & Sinha, S. (2020). Immunogenicity and Safety of a Classical Swine Fever Vaccine in Pigs. International Journal of Livestock Research, 10(6), 127–131. https://doi.org/10.5455/ijlr.20200316015559

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