Case Report on Therapeutic Management of Canine Oral Papillomatosis
Keywords:
Auto Haemotherapy, Canine, Histopathology, Warts, Zinc OxideAbstract
Canine papillomatosis is a frequently encountered viral infection in dogs, particularly in the younger age group. The condition is characterized by the presence of multiple benign epithelial tumours evident on the mucous membrane and skin. The causative agent is papillomavirus; a non-enveloped double-stranded DNA virus; to date, more than 50 genera, at least 318 types of papillomaviruses, affecting over 54 different animal species have been identified. A one-year-old non-descript intact bitch was presented to the Veterinary Clinical Complex, College of Veterinary and Animal Sciences, Pantnagar with the progressive development of multiple cauliflower-like outgrowths on the oral mucous membranes and tongue. Based on clinical examination and histopathology, the condition was diagnosed as canine papillomatosis. Treatment was carried out with injectable lithium antimony thiomalate, auto-haemotherapy, Thuja (homeopathic drug), and topically with zinc oxide ointment which proved to be effective after a few consecutive treatments. This article describes the haematological and histopathologic findings of canine oral papillomatosis and its therapeutic management.References
Araldi, R.P., Assaf, S.M.R., Carvalho, R.F., Carvalho, M., Souza, J.M., Magnelli, R.F., Modolo, D.G., Roperto, F.P., Stocco, R.C. and Becak, W. 2017. Papillomaviruses: A systematic review. Genet. Mol. Biol. (40): 1–21.
Bianchi, M.V., Casagrande, R.A., Watanabe, T.T.N., Wouters, A.T.B., Wouters, F., Boos, G.S., Menegat, M.B. and Driemeier, D. 2012. Canine papillomatosis: a retrospective study of 24 cases (2001-2011) and immunohistochemical characterization. Small Animal Diseases • Pesq. Vet. Bras. 32 (7)
Bodinet, C., Lindequist, U., Teuscher, E. and Freudenstein, J. 2002. Effect of an orally applied herbal immunomodulator on cytokine induction and antibody response in normal and immunosuppressed mice. Phytomedicine. 9:606–13
Borges, OMM., Araújo, CLM., Ramalho, GC., Silva, RMV., Tanikawa, A. and Souza, AP. 2017. Effects of Autohemotherapy on Hematologic Parameters and Morphology of Canine Oral Papillomatosis. Acta Scientiae Veterinariae. 45(1):211.
Bregman, C. L., Hirth, R.S., Sundberg, J.P. and Christensen, E.F. 1987. Cutaneous neoplasms in dogs associated with canine oral papillomavirus vaccine. Veterinary Pathology 24: 477–487
Chang, C., Chen, W., Haga, T., Yamashita, N., Lee, C., Tsuzuki, M., and Chang, H. 2020. The Detection and Association of Canine Papillomavirus with Benign and Malignant Skin Lesions in Dogs. Viruses, 12: 170.
Gohla, SH., Haubeck, HD., Schrum, S., Soltau, H. and Neth, RD. 1989. Activation of CD4-positive T cells by polysaccharide fractions isolated from the Cupressaceae Thuja occidentalis L. (Arborvitae) Haematol Blood Transfus. 35:268–72.
Gross T.L., Ihrke P.J. and Walder E.J. 1992. Veterinary Dermatopathology: A macroscopic and microscopic evaluation of canine and feline skin disease. St Louis (Mo.): Mosby-Year Book.
Gupta, M., Mahajan, V.K., Mehta, K.S., and Chauhan, P.S. 2014. Zinc therapy in dermatology: a review. Dermatol Res Pract.:709152.
Head, KW., Else, RW. and Dubielzig, RR. 2002. Tumors of the alimentary tract. Tumors in Domestic Animals. 4th ed.: 422-423.
Joseph, R., Pulimood, S. A., Abraham, P., and John, G. T. 2013. Successful treatment of verruca vulgaris with Thuja occidentalis in a renal allograft recipient. Indian journal of nephrology, 23(5) : 362–364.
Kaldrymidou, E., Papaioannou, N., Pouta-hidis, T., Garderen, E. and Karayanopoulou, M. 2001. Canine cutaneous papilloma. Study of eleven cases. Bulletin of the Hellenic Veterinary Medical Society 52: 126–134
Khan, S., Kalaiselvan, E., Sindhoora, K., Rahman, A., Faslu, T., Khan, A., Pawde, A.M. and Amarpal. 2020. Oral Papillomatosis in a Dog: Surgical Management and Histopathological Findings. Advances in Animal and Veterinary Sciences, 8:408-411
Lazarczyk, M. and Favre, M. 2008. Role of Zn2+ ions in host-virus interactions. J Virol., 82:11486–11494.
Mettenleiter, M.W. 1936. Auto hemo transfusion in preventing postoperative lung complications. American Journal of Surgery. 32(2):321-323.
Raj, P., Pavulraj, S., Kumar, M. A., Sangeetha, S., Shanmugapriya, R., and Sabithabanu, S. 2020. Therapeutic evaluation of homeopathic treatment for canine oral papillomatosis. Veterinary world, 13(1): 206–213.
Richman, A.W., Kirby, A.L., Rosenkrantz, W. and Muse, R.2017. Persistent papilloma treated with cryotherapy in three dogs. Vet Dermatol. 28(6):625-e154.
Shah K.V. and Howley P.M. 1996. Papilloma viruses. Fields Virology. Third Edition: 2077-2101.
Songsantiphap, C., and Asawanonda, P. 2019. Topical 15% Zinc Oxide Ointment Significantly Reduces the Size of Common Warts After Four Weeks: A Randomized, Triple-blinded, Placebo-controlled Trial. The Journal of clinical and aesthetic dermatology, 12(9): 26–31.
Sundberg J.P., Smith E.K., and Herron A.J. 1994. Involvement of canine oral papillomavirus in generalized oral and cutaneous verrucosis in a Chinese shar pei dog. Vet Pathol 31:183187.
Vail M.D. and Withrow J.S. 2007. Chapter 18 - Tumors of the Skin and Subcutaneous Tissues. Withrow & Mac Ewen's Small Animal Clinical Oncology (Fourth Edition), W.B. Saunders: 375-401
Williams, A., Scally, G. and Langland, J. 2021. A topical botanical therapy for the treatment of canine papilloma virus associated oral warts: A case series. Advances in Integrative Medicine, 8(2): 151-154
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