Histopathological Lesions Associated with Hyperlipidaemia Induced by Cholesterol and Groundnut Oil in Some Tissues of Albino Rats

Authors

  • Olufunke A. Sodipo Department of Clinical Pharmacology and Therapeutics, College of Medical Sciences, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria
  • Halima I. Gambo Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria https://orcid.org/0000-0001-7539-2051
  • Hassan Abdulsalam University of Maiduguri, Borno State https://orcid.org/0009-0000-1448-4817
  • Fanna I. Abdulrahman Department of Chemistry, Faculty of Science, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria
  • Umar K. Sandabe Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria

Keywords:

Hyperlipidaemia, cholesterol, groundnut oil, albino rats

Abstract

The heart, kidney, brain and intestine are tissues associated with hyperlipidaemia, atherosclerosis, ischemia and infarcts. Other tissues may not be so severely affected but may show dysfunctions which can only be seen at histopathology. The effect of oral administration of cholesterol and groundnut oil on some tissues (Heart, lungs, liver, kidney, intestine, spleen and brain) of albino rats was investigated. Ten (10) male albino rats weighing between 155 to 255 g were procured and allowed to acclimatized for 14 days before commencement of the experiment. Rats were fed commercial prepared feed and water ad libitum throughout the experiment. Hyperlipidaemia was induced in the 10 rats by feeding them orally with 1% cholesterol and groundnut (mixed in standard rat feeds) oil for a period of 3 weeks. Thereafter, the rats were humanely sacrificed; tissues were harvested, processed and examined microscopically. The tissue changes observed included interstitial vacuolated mononuclear cell infiltration and marked congestion in the lungs, marked vacuolar degeneration of hepatocytes, mild gliosis and degenerate neuron in the cerebellum, marked hydropic degeneration and necrosis of renal tubular epithelium, marked erythrophagocytosis in the spleen and severe villous matting and mononuclear infiltrates in the small intestine. Thrombosis was evident in coronary vessels. These findings suggested that orally administration of 1% cholesterol and groundnut induced hyperlipidaemia with resultant tissue architectural alterations.

Author Biographies

Olufunke A. Sodipo, Department of Clinical Pharmacology and Therapeutics, College of Medical Sciences, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria

Olufunke A. Sodipo is a Professor of Pharmacology from the Department of Clinical Pharmacology and Therapeutics, College of Medical Sciences, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria

Halima I. Gambo, Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria

Halima I. Gambo is a Reader and consultant Diagnostic Pathologist with Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria

Fanna I. Abdulrahman, Department of Chemistry, Faculty of Science, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria

Fanna I. Abdulrahman is a professor of Chemistry with Department of Chemistry, Faculty of Science, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria

Umar K. Sandabe, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria

Umar K. Sandabe is a Professor of Veterinary Physiology from the Department Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria

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Published

31-07-2024

How to Cite

Sodipo, O. A., Gambo, H. I., Abdulsalam, H., Abdulrahman, F. I., & Sandabe, U. K. (2024). Histopathological Lesions Associated with Hyperlipidaemia Induced by Cholesterol and Groundnut Oil in Some Tissues of Albino Rats. International Journal of Livestock Research, 14(7), 14–20. Retrieved from http://ijlr.org/ojs_journal/index.php/ijlr/article/view/704

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