Histopathological Lesions Associated with Hyperlipidaemia Induced by Cholesterol and Groundnut Oil in Some Tissues of Albino Rats
Keywords:
Hyperlipidaemia, cholesterol, groundnut oil, albino ratsAbstract
The heart, kidney, brain and intestine are tissues associated with hyperlipidaemia, atherosclerosis, ischemia and infarcts. Other tissues may not be so severely affected but may show dysfunctions which can only be seen at histopathology. The effect of oral administration of cholesterol and groundnut oil on some tissues (Heart, lungs, liver, kidney, intestine, spleen and brain) of albino rats was investigated. Ten (10) male albino rats weighing between 155 to 255 g were procured and allowed to acclimatized for 14 days before commencement of the experiment. Rats were fed commercial prepared feed and water ad libitum throughout the experiment. Hyperlipidaemia was induced in the 10 rats by feeding them orally with 1% cholesterol and groundnut (mixed in standard rat feeds) oil for a period of 3 weeks. Thereafter, the rats were humanely sacrificed; tissues were harvested, processed and examined microscopically. The tissue changes observed included interstitial vacuolated mononuclear cell infiltration and marked congestion in the lungs, marked vacuolar degeneration of hepatocytes, mild gliosis and degenerate neuron in the cerebellum, marked hydropic degeneration and necrosis of renal tubular epithelium, marked erythrophagocytosis in the spleen and severe villous matting and mononuclear infiltrates in the small intestine. Thrombosis was evident in coronary vessels. These findings suggested that orally administration of 1% cholesterol and groundnut induced hyperlipidaemia with resultant tissue architectural alterations.
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