Purified Crude Glycerol Fortification to the Diets of Dairy Cows with Conclusive Impacts: A Review

Authors

  • Punith ICAR-National Dairy Research Institute
  • Savitha ICAR-National Dairy Research Institute
  • Bandla Srinivas a:1:{s:5:"en_US";s:38:"ICAR-National Dairy Research Institute";}

Keywords:

By-Product, Energy, Glycogenesis, Lipogenesis, Fermentation, Ruminants, Lactation, Pregnancy

Abstract

The literature analysis and octennial research carried out in our lab on glycerol, a by-product during biodiesel production, use in dairy cows diet provides conclusive inferences on dry matter intake (DMI), nutrient digestibility, energy availability, rumen microbial protein (MBP) production, blood profile, blood metabolites and milk production and milk composition. An adaptation period of 1 week is necessary to adjust dairy cows to the glycerol fortification in the diet. The amount of glycerol fed is also important because of its high energy density. Many of the studies and our results showed that glycerol fortification to the diets either unaffected or marginally improved DMI or other nutritional parameters besides rumen MBP.  The increased milk yield could be attributed to the significant increase in blood glucose (P< 0.01) to the maximum physiological limits. Milk fat percent or yield was also increased from the 2nd week of glycerol fortification to the diet of dairy cows in early lactation. Glycerol fortification in the diets of close-up cows in the last 4 weeks was found effective in the reduction of NEFA and BHBA in fresh cows because metabolically absorbed glycerol into the blood is channelized 70% to gluconeogenesis and 30% to triglyceride synthesis. Conclusively we recommend glycerol fortification to the diets of dairy cows in early lactation and close-up cows at the rate of 300 mL or 360 g/d for improved health and milk production.

Author Biographies

Punith, ICAR-National Dairy Research Institute

P. G. Scholar 

M.V. Sc., (Animal Nutrition)

Southern Regional Station

ICAR-National Dairy Research Institute

Bangalore, India 560030

 

Savitha, ICAR-National Dairy Research Institute

Research Associate

Department of Science & Technology Project

Southenr Regional Station

ICAR-National Dairy Research Institute

Bangalore India 560030

References

Allen M. S., Bradford B.J. and Harvatine K. J. (2005). The cow as a model to study food intake regulation. Annual Review of Nutrition 25: 523-547.

Allen M. S. (2014). Drives and limits to feed intake in ruminants. Animal Production Science 54: 1513-1524.

Allen M. S., Bradford B. J. and Oba M. (2009). Board-invited review: The hepatic oxidation theory of the control of feed intake and its application to ruminants. Journal of Animal Science 87(10): 3317-3334.

Ariko T., Kass M., Henno M., Fievez V., Kärt O., Kaart T. and Ots M. (2015). The effect of replacing barley with glycerol in the diet of dairy cows on rumen parameters and milk fatty acid profile. Animal Feed Science and Technology 209: 69-78.

Bajramaj D, L, Curtis R. V., Kim J., Corredig M., Doelman J., Wright T. C,, Osborne V. R. and Cant. J. P. (2017). Addition of glycerol to lactating cow diets stimulates dry matter intake and milk protein yield to a greater extent than addition of corn grain. Journal of Dairy Science 100(8): 6139–6150.

Bionaz M., Vargas-Bello-Pérez E. and Busato S. (2020). Advances in fatty acids nutrition in dairy cows: from gut to cells and effects on performance. Journal of Animal Science and Biotechnology 11:110-146

Blötz C. and Stülke J. (2017). Glycerol metabolism and its implications in virulence in Mycoplasma. Journal of the Federation of European Microbiological Studies 41:640-652.

Boyd J, Bernard J. K. and West J. W. (2013). Effects of feeding different amounts of supplemental glycerol on ruminal environment and digestibility of lactating dairy cows. Journal of Dairy Science 96(1): 470–476.

Chung Y. H., Rico D. E., Martinez C. M., Cassidy T. W., Noirot V., Ames A. and Varga G. A. (2007). Effects of feeding dry glycerine to early postpartum Holstein dairy cows on lactational performance and metabolic profiles. Journal of Dairy Science 90(12): 5682-5691.

de Andrade G. P., de Carvalho F. F. R., Batista Â. M. V., Pessoa R. A. S., da Costa C. A., Cardoso D. B. and do Vale Maciel M. (2018). Evaluation of crude glycerine as a partial substitute of corn grain in growing diets for lambs. Small Ruminant Research 165:41-47.

DeFrain J. M., Hippen A. R., Kalscheur K. F. and Jardon P. W. (2004). Feeding glycerol to transition dairy cows: effects on blood metabolites and lactation performance. Journal of Dairy Science 87(12): 4195–4206.

Doi Y. (2019). Glycerol metabolism and its regulation in lactic acid bacteria. Applied Microbiology and Biotechnology 103(13): 5079–5093.

Donkin S. S., (2008). Glycerol from biodiesel production: The new corn for dairy cattle. Revistabrasileira de zootecnia, 37(SPE): 280-286.

Donkin S. S. and Doane, P. (2007). Glycerol as a feed ingredient in dairy rations. 2007. Tri-State Dairy Nutrition Conference, Fort Wayne, Indiana, USA, 24-25 April 2007 (pp. 97-103). Ohio State University.

Donkin S. S., Pallatin M. R., Doane P. H., Cecava M. J., White H. M., Barnes E. and Koser S L. (2007). January. Performance of dairy cows fed glycerol as a primary feed ingredient. In Journal of Dairy Science (Vol. 90, pp. 350-350). 1111 N DUNLAP AVE, SAVOY, IL 61874 USA: AMERICAN DAIRY SCIENCE ASSOCIATION.

Drackley J. K. (2008). June. Opportunities for glycerol use in dairy diets. In Proceedings of the4th State Dairy Nutrition and Management Conference, Dubuque. SDN, Dubuque (pp. 113-118).

Eranna Lokesha and Srinivas Bandla. (2018). Evaluation of additive effect of feed additives in crossbred cows under in vitro and in vivo conditions. Indian Journal of Animal Research10.18805/ijar.B-3581.

Ezequiel, J. M. B., Sancanari, J. B. D., Neto O. M., Da Silva Z. F., Almeida M. T. C., Silva D. A. V. and Van Cleef E. H. C. B. (2015). Effects of high concentrations of dietary crude glycerin on dairy cow productivity and milk quality. Journal of Dairy Science98(11): 8009-8017.

Ferraro S M., Mendoza G D., Miranda L. A. and Gutiérrez C. G. (2016). In vitro ruminal fermentation of glycerol, propylene glycol and molasses combined with forages and their effect on glucose and insulin blood plasma concentrations after an oral drench in sheep. Animal Feed Science and Technology 213: 74-80.

Forbes J. M., (1992). Metabolic aspects of satiety. The Proceedings of the Nutrition Society 51(1): 13–19.

Friedrich S. (2003). A worldwide review of the commercial production of Biodiesel: a technological, economic and ecological investigation based on case studies.

Gaillard C, Sørensen M. T., Vestergaard M., Weisbjerg M. R., Larsen M. K., Martinussen H. and Sehested J. (2018). Effect of substituting barley with glycerol as energy feed on feed intake, milk production and milk quality in dairy cows in mid or late lactation. Livestock Science 209: 25-31.

Gibellini F. and Smith T. K. (2010). The Kennedy pathway DeNovo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB life 62(6): 414–428.

Goff J. and Horst R. (2001).Oral glycerol as an aid in the treatment of ketosis/fatty liver complex Journal of Dairy Science 84:153.

Gomes Marco Antonio Bensimon, Gentil Vanini de Moraes, Marcela Mataveli, Francisco de Assis Fonseca de Macedo, Thais Cristina Carneiro and Robson Marcelo Rossi. (2011). "Performance and carcass characteristics of lambs fed on diets supplemented with glycerine from biodiesel production. Revista Brasileira de Zootecnia 40: 2211-2219.

Gorka P, Kowalski Z. M., Pietrzak P., Kotunia A., Kiljanczyk R., Flaga J., Holst J. J., Guilloteau P. and Zabielski R. (2009). Effect of sodium butyrate supplementation in milk replacer and starter diet on rumen development in calves. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society 60 Suppl 3: 47–53.

Grummer R. R., Mashek D. G. and Hayirli, A. (2004). Dry matter intake and energy balance in the transition period. Vetetinary Clinics: Food Aimal Practice, 20: 447-470.

Gunn P. J., Neary M. K., Lemenager R. P. and Lake S. L. (2010). Effects of crude glycerine on performance and carcass characteristics of finishing wether lambs. Journal of Animal Science 88(5): 1771–1776.

Guo Z. K. and Jensen M. D. (1999). Blood glycerol is an important precursor for intramuscular triacylglycerol synthesis. The Journal for Biological Chemistry 34:23702-23706.

Izumi K., Fukumori R., Oikawa S. and Oba M. (2019). Effects of butyrate supplementation on the productivity of lactating dairy cows fed diets differing in starch content. Journal of Dairy Science 102(12): 11051-11056.

Jensen M. D., Chandramouli V., Schumann W. C., Ekberg K., Previs S F., Gupta S. and Landau B. R. (2001). Sources of blood glycerol during fasting. American Journal of Endocrinology and Metabolism 281: E998-E1004.

Jin E. S., Sherry A. D., and Malloy C. R. (2013). Metabolism of glycerol, glucose and lactate in the citric acid cycle prior to incorporation into hepatic acylglycerols. Journal of Biochemistry 288:14488-14496.

Kass M., Ariko T., Samarütel J., Ling K., Jaakson H., Kaart T. and Ots M. (2013). Long-term oral drenching of crude glycerol to primiparous dairy cows in early lactation. Animal Feed Science and Technology 184: 58-66.

Khalili H., Varvikko T., Toivonen V., Hissa K. and Suvitie M. (1997). The effects of added glycerol or unprotected free fatty acids or a combination of the two on silage intake, milk production, rumen fermentation and diet digestibility in cows given grass silage-based diets. Agricultural and Food Science 6: 349-362.

Kholif A. E. (2019). Glycerol use in dairy diets: A systemic review. Animal nutrition 5(3): 209–216.

Kholodenko B. N., Cascante, M. and Westerhoff H. V. (1995). Control theory of metabolic channeling. Molecular and Cellular Biochemistry 143(2):151-168.

Kijora C., Bergner H., Götz K. P., Bartelt J., Szakács J. and Sommer A. (1998). Research Note: investigation on the metabolism of glycerol in the rumen of bulls. Archiv fur Tierernahrung 51(4): 341–348.

Kristensen, N. B. and Raun B. M. L. (2007). Ruminal fermentation, portal absorption and hepatic metabolism of glycerol infused into the rumen of lactating dairy cows. Publication-European Association for Animal Production 124: 355-361.

Kupczyński R., Szumny A., Wujcikowska K. and Pachura N. (2020). Metabolism, Ketosis Treatment and Milk Production after Using Glycerol in Dairy Cows: A Review. Animals: 10(8): 1379-1386.

Lager K. and Jordan E. (2012). The metabolic profile for the modern transition dairy cow. In Mid-South Ruminant Nutrition Conference (pp. 9-16).

Lammers P. J., Honeyman M. S., Bregendahl K., Kerr B., Weber T. E., Dozier W. A. and Kidd M. (2007). Energy value of crude glycerol fed to pigs. Iowa State University Animal Industry Report 4(1):1-2.

Linke P. L., DeFrain J. M., Hippen A. R., and Jardon P. W. (2004). Ruminal and plasma responses in dairy cows to drenching or feeding glycerol. Journal of Dairy Science 87(Suppl 1): 343-349.

Lomander H., Frössling J., Ingvartsen K. L., Gustafsson H. and Svensson C. (2012). Supplemental feeding with glycerol or propylene glycol of dairy cows in early lactation--effects on metabolic status, body condition, and milk yield. Journal of Dairy Science 95(5): 2397–2408.

Madrid J., Villodre C., Valera L., Orengo J., Martínez S., López M. J. and Hernández F. (2013). Effect of crude glycerine on feed manufacturing, growth performance, plasma metabolites, and nutrient digestibility of growing-finishing pigs. Journal of Animal Science 91(8): 3788-3795.

Maxin G., Rulquin H. and Glasser F. (2011). Response of milk fat concentration and yield to nutrient supply in dairy cows. Animals 5: 1299-1310.

Meher L. C., Kulkarni M. G., Dalai A. K. and Naik, S. N. (2006). Transesterification of karanja (Pongamia pinnata) oil by solid basic catalysts. European Journal of Lipid Science and Technology. 108: 389-397.

NRC (2001). Nutrient requirements of dairy cattle. Seventh Revised Edition. National Research Council, National Academy of Sciences. Washington, D.C.

Ogborn K. (2006). Effects of method of delivery of glycerol on performance and metabolism of dairy cows during the transition period.

Omazic A. W., Tråvén M., Bertilsson J. and Holtenius K. (2013a). High and low-purity glycerine supplementation to dairy cows in early lactation: effects on silage intake, milk production and metabolism. Animal: An international journal of animal bioscience 7(9): 1479–1485.

Omazic A. W., Tråvén M., Roos S., Mellgren E. and Holtenius K. (2013b). Oral rehydration solution with glycerol to dairy calves: effects on fluid balance, metabolism, and intestinal microbiota. Acta Agriculturae Scandinavica, Section A–Animal Science 63(1): 47-56.

Orengo J., Madrid J., Aragón J. L., Martínez-Miró S., López M. J. and Hernández F. (2021). The Effect of the Dietary Inclusion of Crude Glycerine in Pre-Starter and Starter Diets for Piglets. Animals: 11(5): 1249.

Osman M., Mehyar N., Bobe G., Coetzee J. F. and Beitz D. C. (2006). Acute effects of subcutaneous injection of glucagon and/or oral administration of glycerol on blood metabolites and hormones of Holstein dairy cows affected with fatty liver disease. Iowa State University Animal Industry Report 3(1): 230-256

Paiva P. G., Del Valle T. A., Jesus E. F., Bettero V. P., Almeida G. F., BueNo I. C. S. and Rennó F. P. (2016). Effects of crude glycerine on milk composition, nutrient digestibility and ruminal fermentation of dairy cows fed corn silage-based diets. Animal Feed Science and Technology 212: 136-142.

Pasciu V., Sotgiu F. D., Procu C. and Berlinguer F. (2021). Effect of Media with Different Glycerol Concentrations on Sheep Red Blood Cells Viability In Vitro. Animals 11: 1592-1603.

Phanthavong V., Preston T. R. and Leng R. A. (2017). Glycerol supplementation increased growth rates, decreased the acetate: propionate ratio in rumen VFA, and reduced enteric methane emissions, in cattle fattened on cassava pulp-urea, brewers’ grains and rice straw. Livestock Research for Rural Development. 29: Article #36.

Porcu C., Manca C., Cabiddu A., Dattena M., Gallus M., Pasciu V. and Molle G. (2018). Effects of short-term administration of a glucogenic mixture at mating on feed intake, metabolism, milk yield and reproductive performance of lactating dairy ewes. Animal Feed Science and Technology 243: 10-21.

Rémond B., Souday E. and Jouany J. P. (1993). In vitro and in vivo fermentation of glycerol by rumen microbes. Animal Feed Science and Technology 41(2): 121-132.

Roger V., Fonty G., Andre C. and Gouet P. (1992). Effects of glycerol on the growth, adhesion, and cellulolytic activity of rumen cellulolytic bacteria and anaerobic fungi. Current Microbiology 25(4): 197–201.

Rotondo F., Ho-Palma A. C. and Remesar, X. (2017). Glycerol is synthesized and secreted by adipocytes to dispose of excess glucose, via glycerogenesis and increased acyl-glycerol turnover. Scientific Reports 7: 8983.

Russell J B. (2007). The energy spilling reactions of bacteria and other organisms. Journal of Molecular Microbiology and Biotechnology 13:1–11.

Saleem A. M. and Singer A. M. (2015). Growth performance and digestion of growing lambs fed diets supplemented with glycerol. Animal 12:959-963.

Saleem A. M., Zanouny A. I., and Singar A. M. (2018). Effect of glycerol supplementation during early lactation on milk yield, milk composition, nutrient digestibility and blood metabolites of dairy buffaloes. Animal: An international journal of animal bioscience 12(4): 757–763.

Schröder A. and Südekum K. H. (1999). September. Glycerol as a by-product of biodiesel production in diets for ruminants. In International Rapeseed Congress (Vol. 10, p. 241).

Shin J. H., Wang D., Kim S. C., Adesogan A. T. and Staples C. R. (2012). Effects of feeding crude glycerine on performance and ruminal kinetics of lactating Holstein cows fed corn silage- or cottonseed hull-based, low-fiber diets. Journal of dairy science 95(7): 4006–4016.

Silva L. G. D., Torrecilhas J. A., Ornaghi M. G., Eiras C. E., Prado R. M. D. and Prado I. N. D. (2014). Glycerine and essential oils in the diet of Nellore bulls finished in feedlot: animal performance and apparent digestibility. Acta Scientiarum, Animal Sciences 36: 177-184.

Srinivas B., and Chaturvedi O. H. (2019). Prosopis juliflora (Sw.) DC. as cattle feed: Toxicity and palatability of different parts, and fermentation kinetics in vitro.

Südekum K. H. (2008). Co-products from biodiesel production. In Recent advances in animal nutrition. 41st University of Nottingham Feed Conference, Sutton Bonington Campus, Nottingham, UK, 4-6 September 2007. (pp. 201-219). Nottingham University Press.

Syahniar T. M., Andriani M., Ridla M., Laconi L. B., Nahrowi N. and Jayanegara J. (2020). Glycerine as a feed supplement for beef and dairy cattle: A meta-analysis on performance, rumen fermentation, blood metabolites and product characteristics. Journal of Animal Physiology and Animal Nutrition 1-12.

Thoh D., Pakdeechanuan P. and Chanjula P. (2017). Effect of supplementary glycerine on milk composition and heat stability in dairy goats. Asian-Australasian journal of animal sciences 30: 1711–1717.

Trabue S., Scoggin K., Tjandrakusuma S., Rasmussen M. A. and Reilly P. J. (2007). Ruminal fermentation of propylene glycol and glycerol. Journal of agricultural and food chemistry 55(17): 7043–7051.

Van Cleef E. H. C. B., Almeida M. T. C., Perez H. L., Paschoaloto J. R., Castro Filho E. S. and Ezequiel J. M. B. (2018). Effects of partial or total replacement of corn cracked grain with high concentrations of crude glycerine on rumen metabolism of crossbred sheep. Small Ruminant Research 159: 45-51.

Van Cleef E. H. C. B., Ezequiel J. M. B., D'Aurea A. P., Fávaro V. R. and Sancanari J. B. D. (2014). Crude glycerine in diets for feedlot Nellore cattle. RevistaBrasileira de Zootecnia 43: 86-91.

Wang C., Liu Q., Huo W. J., Yang W. Z., Dong K. H., Huang Y. X. and Guo G. (2009a). Effects of glycerol on rumen fermentation, urinary excretion of purine derivatives and feed digestibility in steers. Livestock Science, 121(1): 15-20.

Wang C., Liu Q., Yang W. Z., Huo W. J., Dong K. H., Huang Y. X., and He D C. (2009b). Effects of glycerol on lactation performance, energy balance and metabolites in early lactation Holstein dairy cows. Animal Feed Science and Technology, 151(1-2): 12-20.

Werner Omazic A., Kronqvist C., Zhongyanz L., Martens H. and Holtenius K. (2015). The fate of glycerol entering the rumen of dairy cows and sheep. Journal of Animal Physiology and Animal Nutrition 99: 258-264.

Wilson K. and Clark J. H. (2000). Solid acids and their use as environmentally friendly catalysts in organic synthesis. Pure and Applied Chemistry. 72: 1313-1319.

Yuasa H., Hamamoto K., Dogu S. Y., Marutani T., Nakajima A., Kato T., Hayashi Y., Inoue K. and Watanabe J. (2003). Saturable absorption of glycerol in the rat intestine. Biological and Pharmaceutical Bulletin 26(11): 1633–1636.

Zijlstra R. T., Menjivar K., Lawrence E., Beltranena E. (2009). The effect of feeding crude glycerol on growth performance and nutrient digestibility in weaned pigs. Canadian Journal of Animal Science 89(1): 85-89.

Downloads

Published

31-07-2022

How to Cite

G V, P. K., G, S., & Srinivas, B. (2022). Purified Crude Glycerol Fortification to the Diets of Dairy Cows with Conclusive Impacts: A Review. International Journal of Livestock Research, 12(7), 1–13. Retrieved from https://ijlr.org/ojs_journal/index.php/ijlr/article/view/90

Similar Articles

1 2 > >> 

You may also start an advanced similarity search for this article.