Anthelmintic Activity of Curcuma longa Ethanolic Extract against Benzimidazole Resistant Gastrointestinal Nematodes in Goats

Abstract

This paper describes the in vivo anthelmintic activity of Curcuma longa hydro alcoholic rhizome extract (CHE 50:50) in naturally infected benzimidazole resistant gastrointestinal nematodes of goats maintained in a farm. Thirty non-descript goats, infected with gastrointestinal nematodes were divided into three groups of ten animals each consisting of Group A (untreated controls), Group B (ABZ at 7.5mgkg^-1 body weight) and Group C (CHE at 500mgkg^-1 body weight). Prior to conducting faecal egg count reduction test (FECRT), egg hatch assay (EHA) was performed by pooling samples from each group showing ED₅₀ value 0.594 indicating high resistance to benzimidazole. Faecal egg count reduction of 64% and 66% on day 10 post-infection was observed in albendazole treated and CHE treated goats, respectively.