The study was conducted on 24 non-descript stall fed goats of both sex and 3 months to 4 years old. Out of 24 goats, 16 were diagnosed as sufferers from respiratory disease on the basis of clinical manifestations such as mucopurulent to serous nasal discharge, coughing, breathing pattern, respiratory sounds, increased rectal temperature, elevated respiration rate and elevated heart rate, and 8 were normal healthy. In order to elucidate the hematobiochemical changes in respiratory disease of goats, blood samples were collected from jugular veins in EDTA and serum vials. Sterilized deep nasal swabs were collected from infected animals after cleaning the nostrils with 70 % alcohol cotton swabs and subjected for bacterial isolation and antibiotic sensitivity test. On the basis of ABST, moxifloxacin was used to treat the infected animals with supportive therapy. A significant decrease in the mean hemoglobin concentration, hematocrit (PCV), Lymphocyte count, total protein, albumin, A: G ratio and phosphorus values were observed among infected goats as compared to healthy goats. Total leucocyte counts, neutrophil counts, eosinophils, serum calcium, serum globulins, blood urea nitrogen (BUN), creatinine, aspartate transaminase (AST) and alanine transaminase (ALT) were significantly higher in infected goats as compared to healthy goats. Moxifloxacin at a dose rate of 5 mg/kg bodyweight found 100% effective in treatment of naturally infected cases of respiratory disease in goats.