Oxfendazole in Combating Gastrointestinal Nematodes of Sheep and Goats

G. Dilip Reddy; Y. Muralidhar; V. Gnani Charitha; V. Surya Prasad; M. Alpha Raj

Authors

G. Dilip Reddy Department of Pharmacology & Toxicology, Sri Venkateswara Veterinary University, College of Veterinary Science, Proddatur– 516360, Andhra Pradesh, INDIA
Y. Muralidhar Department of Pharmacology & Toxicology, Sri Venkateswara Veterinary University, College of Veterinary Science, Proddatur– 516360, Andhra Pradesh, INDIA
V. Gnani Charitha Department of Parasitology, Sri Venkateswara Veterinary University, College of Veterinary Science, Proddatur– 516360, Andhra Pradesh, INDIA
V. Surya Prasad Veterinary Services, Indian Immunologicals Limited, Rakshapuram, Gachibowli, Hyderabad, Telangana- 500032, INDIA
M. Alpha Raj Department of Pharmacology & Toxicology, Sri Venkateswara Veterinary University, College of Veterinary Science, Proddatur– 516360, Andhra Pradesh, INDIA

Keywords:

Efficacy, Goats, Nematodes, Oxfendazole, Sheep

Abstract

The environment and the farm practices of tropical and subtropical countries are congenial for various parasite infestations with reduced productivity in sheep and goats. The sulphoxide metabolite of fenbendazole, oxfendazole gains peak blood levels slowly, assuring maintenance of effective concentrations for a longer time. This improves the efficacy against immature larvae. The present study deals with the safety and efficacy of oxfendazole in sheep and goats. The reduction in egg per gram (EPG) count in treated and control groups was used to measure efficacy. No serious adverse events were observed in the study animals. Oxfendazole was effective in reducing the EPG by over 90% within 7 days of treatment denoting its efficacy in combating the parasitic infestation.