Vaccinology combines disciplines of immunology, microbiology, protein chemistry, and molecular biology with practical considerations of production costs, regulatory affairs, and commercial returns. Veterinary vaccines already made enormous impacts not only on animal health, welfare, and production but also on human health. To control parasitic diseases in animals, vaccines are considered as a better alternative. However, most important barrier in the development of parasitic vaccine is incomplete understanding of the molecular and immune regulatory pathways involved in the development of immunity against parasitic diseases as well as lack of precise understanding of the host/parasite interaction.