Evaluation of Acute Oral Toxicity of a Phytogenic Essential Oil-Based Anti-Diarrhoeal and Gut Function Modulator

Vikas Vasant Karande; Vaishnavi Sanjay Gagare; Sunidhi; Ravikanth Kotagiri; Bhaskar Ganguly

doi:10.5455/ijlr.20201023040029

Authors

Vikas Vasant Karande Assistant Professor, Department of Pharmacology and Toxicology, Krantisinh Nana Patil College of Veterinary Science, Shirwal, Satara, Maharashtra, INDIA
Vaishnavi Sanjay Gagare M.V.Sc. Scholar, Department of Pharmacology and Toxicology, Krantisinh Nana Patil College of Veterinary Science, Shirwal, Satara, Maharashtra, INDIA
Sunidhi Research Associate, Research and Development Unit, Ayurvet Limited, Baddi, Himachal Pradesh, INDIA
Ravikanth Kotagiri Director, Operations & Research, Research and Development Unit, Ayurvet Limited, Baddi, Himachal Pradesh, INDIA
Bhaskar Ganguly Senior Scientist, Research and Development Unit, Ayurvet Limited, Baddi, Himachal Pradesh, INDIA

DOI:

https://doi.org/10.5455/ijlr.20201023040029

Keywords:

Acute Oral Toxicity, Limit Test, Liqbiotic™, OECD 423, Safety

Abstract

A study was undertaken to evaluate the acute oral toxicity potential of Liqbiotic™ (M/s Ayurvet Limited, India) according to OECD 423 guidelines. Liqbiotic™ is an anti-diarrhoeal and gut function modulator for poultry and pigs. Six (3 male and 3 female) Swiss albino mice were used for the study, where each animal served as its own control. The animals were observed for the manifestation of toxic effects and mortality following the oral administration of the limit dose of test substance @ 2000 mg/kg body weight. No toxic effects or mortalities were observed till 14 days and Liqbiotic™ was found to be safe for oral use.

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