Testicular Toxicity Induced by Glyphosate (GLP) and Ameliorative Effect of  Vitamin C in Wistar Rats

M. Lakshmi Namratha; M. Lakshman; M. Jeevanalatha; B. Anil Kumar

doi:10.5455/ijlr.20191012074803

Authors

M. Lakshmi Namratha Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, INDIA
M. Lakshman Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, INDIA https://orcid.org/0000-0002-1873-9343
M. Jeevanalatha Department of Veterinary Pathology, College of Veterinary Science, Mamnoor-506166, INDIA
B. Anil Kumar Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, INDIA

DOI:

https://doi.org/10.5455/ijlr.20191012074803

Keywords:

Glyphosate, Testicular Toxicity, Testosterone and Histopathology, Vitamin C

Abstract

The aim of the present experiment was to study the testicular toxicity induced by glyphosate and the
protective role of Vitamin C in male albino Wistar rats. Forty eight (48) rats were randomized into four
groups consisting of twelve (12) animals in each: Group 1 served as control, group 2 received glyphosate
at a dose of 500 mg/kg b.wt, group 3 received Vitamin C at a dose of 250 mg/kg b.wt and group 4 received
glyphosate (500 mg/kg b.wt) and Vitamin C (250 mg/kg b.wt). The treatment regimens were administered
by oral gavage once daily for three weeks. The animals were sacrificed on 7th and 21st day post treatment.
Results showed a significant increase in the percentage of abnormal sperms, reduction in the levels of
testosterone and histopathological changes in the testes of glyphosate treated rats. However,
administration of Vitamin C caused a mild to moderate ameliorative effect on the parameters investigated.