NAAS Score 2019


Declaration Format

Please download DeclarationForm and submit along with manuscript.


Free counters!

Previous Next

Effect of Adiponectin on Proliferation of Granulosa and Luteal Cells of Buffalo Ovary

Mahesh Gupta Ankita Thakre J. P. Korde K. B. Bahiram V. M. Sardar S. D. Dudhe
Vol 9(4), 195-205

Adiponectin is an adipocyte derived cytokine involved in various metabolic functions. The present study was conducted to determine the effect of adiponectin on proliferation and apopotosis of granulosa and luteal cells of buffalo ovary. Granulosa and luteal cells were cultured in vitro and treated with adiponectin each at 1 and 10 ug/mL concentrations for 48h after obtaining 75% to 80% confluence. Real time PCR was used to demonstrate the relative expression of proliferation marker PCNA and apoptosis marker BAX and signaling molecule PDK and Akt. The results showed that adiopnectin at the dose 10 ug/mL increased mRNA expression of PCNA, Akt, PDK (P<0.05) and decreased mRNA expression apoptosis marker BAX in presence of FSH (30 ng/mL) and IGF-I (10ng/mL). In luteal cell culture adiponectin did not affect the proliferation or apoptosis at both doses. To conclude, this study provides the evidence that adiponectin have positive effect on cell proliferation and it varies in different tissues.

Keywords : Adiponectin Apoptosis Buffalo Proliferation

Full Text Read : 404 Downloads : 77
Previous Next

Submit Case Reports for Special Issue (Dec’19)

Recommend IJLR to include in UGC-CARE list

Download Completed format here

IJLR_UGC CARE Recommendation


Recommendations of new journals should be routed by universities and colleges as follows:

  1. Universities: IQAC cell to respective regional CARE University
  2. Affiliated colleges: College IQAC cell to parent university’s IQAC cell. Parent university IQAC cell will forward to respective regional CARE University.

You can find Zonal UGC-CARE address here