A study was conducted to establish the epidemiology of haemoprotozoan infections in cattle from Marathwada region. The present study was carried out from January 2018 to June, 2019. On blood smear examination, an overall prevalence was 7.52% (138 out of 1835) for haemoprotozoan infections with maximum prevalence of Theileriosis (5.83%) followed by Babesiosis (0.38%) and Anaplasmosis (0.11%) with mixed infection prevalence of 0.60% each Theileriosis and Babesiosis as well as Theileriosis and Anaplasmosis. Crossbred cattle (10.19%) were found to be more susceptible to haemoprotozoan infections than indigenous cattle (5.92%). Age-wise high rate of infection was in 2-5-year age group (9.48%) followed by 7.47% in > 5-year age group, 6.48% in 6 month-2-year age group while 4.18% in calves < 6 months with higher prevalence in females (9.18%) as compared to males (5.79%). The prevalence was found to be higher in lactating (10.30%) cows than pregnant one (7.46%). Highest prevalence was recorded during winter season (9.96%) followed by post monsoon (9.38%), summer (8.03%) and monsoon (4.48%). High milk yield (36.96%), heavy workload (20.29%), change in geographical location (15.94%), transportation (13.77%) and hot climate (10.87%) were observed as major predisposing factors.