Study was conducted to evaluate hematological and tissue biochemical profile in doxorubicin induced testicular toxicity and its amelioration by quercetin. A total of 48 male albino rats (Wistar strain) were randomly divided into 4 groups consisting of 12 in each group. Group 1-control, Group 2-Doxorubicin treated @4mg/kg b.wt intraperitoneally weekly once. Group 3-treated with quercetin @ 80mg/kg b.wt, orally daily. Group 4-treated with doxorubicin @ 4 mg/kg b.wt, intraperitoneally weekly once and quercetin @ 80mg/kg b.wt, orally daily. Hematological studies revealed that overall mean values of PCV, Hb, TEC, TLC were significantly (P<0.05) reduced in group 2. Studies on tissue oxidative parameters revealed significant (P<0.05) increase of TBARS and significant (P<0.05) decrease of GSH, SOD, CAT and testicular LDH in group 2 compared with control. Improvement was noticed in all the above parameters in Group 4 in comparison with Group 2.