The present study was conducted to investigate pathomorphological changes in chlorpyrifos toxicity in broilers. Group I served as control while group II, III and IV birds were given Chlorpyrifos @3.2, 1.6 and 0.64 mg/kg, respectively, orally in corn oil for a period of 6 weeks. The birds were sacrificed by humane method. Representative tissues from the affected regions of various organs were collected in 10% buffered formalin. Tissue samples were processed for routine paraffin embedding technique and 5 micron thin section were stained with Haris’ Haematoxylin and Eosin stain. Histopathologically, liver of all the treatment group birds showed hepatocytic degeneration and necrosis, Mononuclear cell infiltration (MNC) and fibrosis in portal area, degeneration and swelling of epithelial cells of Proximal Convoluted Tubule’s obliterating lumen and presence of MNC in kidneys, engorgement of cerebral blood vessel with increased perivascular space,shrunken deeply eosinophilic neurons, MNC leading to leptomeningitis in brain.