Comparison of Therapeutic Efficacy of Ceftriaxone-Tazobactam with Amoxicillin- Clavulanic Acid in Dogs Suffering From Urinary Tract Infection

Abstract

The present study was conducted to evaluate the therapeutic efficacy of ceftriaxone-tazobactam and amoxicillin-clavulanic acid in dogs suffering from urinary tract infection.  Out of 22 dogs diagnosed with urinary tract infection, 12 dogs were administered antibiotics based on antibiotic sensitivity pattern. Two groups were made each having six dogs. In group A, ceftriaxone-tazobactam was administered @20 mg per kg BW once daily by IM route for 5 days and in group B amoxicillin-clavulanic acid was administered @20 mg per kg BW twice daily by oral route for 7 days. Therapeutic efficacy was determined on the basis of remission of clinical signs and effect on haemato-biochemical parameters. Sampling for evaluation of haemato-biochemical alteration was done on day 0 and 3 of the treatment.  Results of therapy revealed group A therapy to be more effective as compared to group B therapy on the basis of remission of clinical signs. Blood urea and creatinine values decreased significantly in group A whereas non-significant alteration was seen in group B dogs. However, normalization of phosphorous values was significant in both the groups.