Immune-mediated hemolytic anemia (IMHA) is the most common immune-mediated diseases associated with production of anti-red blood cell (RBC) antibodies in dogs. It causes severe anemia, morbidity and mortality in dogs. The present study records the haematological changes in dogs affected with IMHA. Anaemic dogs presented to Teaching Veterinary Clinical Complex Kokkale, Thrissur were diagnosed with IMHA by performing saline agglutination test and direct Coombs’ test. Twenty five dogs positive for IMHA were studied for haematological changes on day of presentation. These dogs were characterized by macrocytic hyperchromic, regenerative type of anaemia with anisocytosis, thromobocytopenia, Leucocytosis, lymphocytosis, monocytosis and granulocytosis. The results indicate that dogs affected with IMHA have significant changes in haematological parameters.