The experiment was conducted on one hundred turkey birds to study the influence of sex on the blood biochemical parameters. Turkey birds with the age ranging between 8-10, 11-13, 14-16, 17-19 and above 26 weeks were grouped as Group 1, 2, 3, 4 and 5, respectively each containing 20 turkey birds, 10 of either sex. All the serum biochemical estimations were carried on automatic biochemical analyzer following the manufactures protocol and instructions. Serum total proteins and serum albumin values were significantly higher in males than in females. Sex plays a non-significant role in the serum concentrations of the globulin. There was a significant effect of sex on level of glucose in turkeys of all age groups. Serum triglycerides values in males were lower than the values in females except in adult turkeys. The males were having a higher mean serum cholesterol level than that of the female studied in the experiment. In conclusion, there was a significant influence of sex on biochemical parameters like total protein, albumin, glucose, triglycerides and LDL cholesterol except globulin.