In the present study, 70 sheep naturally infected with gastro-intestinal nematodes and having at least 150 eggs per gram (EPG) count were selected and grouped into four groups i.e. T1, T2, T3 and T4. Group T1, T2 and T3 were treated with fenbendazole (@ 5 mg/kg b.wt. orally), closantel (@ 10 mg/ kg b.wt. orally) and levamisole (@ 7.5 mg/kg b.wt. subcutaneously), respectively while, Group T4 served as untreated control. Faecal samples were collected on 11th day post treatment from animals of all groups and individual faecal counts were done by modified McMaster technique. The faecal egg count reduction percentage in groups T1, T2, and T3 was 80.1, 96.02 and 72.39, respectively, indicating moderate resistance against fenbendazole and levamisole. Coprocultures from pre- and post-treatment faecal cultures revealed the predominance of Haemonchus contortus larvae.