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Evaluation of Hematological, Serum Biochemical and Tissue Antioxidant Changes in Experimentally Induced Hyperlipidemia in Wistar Albino Rats

Srinivasa Naik H. Srilatha Ch.1 Sujatha K. Sreedevi B. Prasad T. N. V.K. V.
Vol 8(2), 84-91

Hyperlipidemia is the disorder of lipid metabolism, characterized by elevated serum total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoproteins cholesterol (VLDL-C) and decreased high density lipoprotein cholesterol (HDL-C). The present study was carried out by procuring 24 Wistar albino rats, divided into two groups consisting of 12 rats in each group. Hyperlipidemia was induced by hyperlipidemic diet consisting of 1% cholesterol and 15% saturated oil added to the 1000g of standard rat diet and given to group II rats. Group I kept as control and fed with standard rat diet. Sacrifice of the rats was done on 45 and 90 day of the experiment and six rats from each group were randomly selected for sacrifice. Group II rats clinically showed obesity with significant increase (p<0.05) in the body weight. Rats were sluggish with poor hair coat. Total leucocyte count (TLC), TC, TG, LDL-C, VLDL-C were significantly (p<0.05) higher, whereas HDL-C was significantly reduced in group II. Oxidative damage indicators like catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced glutathione (GR) and glutathione-S-transferase (GST) were significantly (p < 0.05) reduced, whereas lipid peroxidation products of thiobrarbituric acid reactive substance (TBARS) level was non-significantly (p < 0.05) increased in liver and heart tissues of hyperlipidemic diet fed group (Group II) compared to group I. Clinical pathological parameters like total erythrocyte count (TEC), total leukocyte count (TLC), packed cell volume (PCV) and hemoglobin estimation was carried out and results of TEC, PCV and Hb% were normal and non-significant (P < 0.05) throughout the experimental period in both the groups I and II, where as TLC in group II was non significantly higher when compared to group I.

Keywords : Biochemical Parameter Hyperlipidemia Hemotology Tissue Antioxidants Wistar Rats

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